When I first woke up and started sensing people, including these "organic portals", I was really creeped out by them because I definitely had that strange feeling that they were soulless. And this really, really bothered me... not just that they felt soulless, but that I was actually thinking they might be, and what did that say about me?
So I've actually meditated quite a bit on this issue. And not long ago, a possible answer came to me (at least, an answer relative to my own Path, your mileage may vary, I'm sure you all know what I mean)...
That answer involved the upcoming singularity and during our approach to it, the rapid convergence of spiritual paths and timelines (and as this convergence is bidirectional, a corresponding splintering of timelines as well). The quickening and merging of parallel universes and such.
The idea was that these "organic portals" are not truly "soulless" at the higher levels. They're just soulless in this timeline, the one I'm currently in. Whether it was at a traumatic point at any point in life, or some change in spiritual lesson plan based on early childhood events, or even a "nah, nevermind" choice made while still in the womb, at some point a soul *did* inhabit a portal's body... they just don't anymore in this timeline, because the path that soul needed to take was in a different direction. In that soul's actual desired timeline, the body that they inhabit (be it equivalent to the organic portal body, or a totally new one) is very much ensouled, and is obvious as such. Just not here.
The thing is, this kind of thing happens constantly, and has been happening since the beginning of forever (as all time is illusory anyway). The thing that makes our current situation different and the OPs much more apparent is because of this convergence of timelines and this reunion of global consciousness. This kind of thing has always been happening, but we weren't aware of it, simply because we're more aware now *in general* than we were before, and this will continue to escalate until the singularity itself. Before this convergence, the alternate timelines where OPs would reside would generally be so far into the realm of the "invisible elsewhere" (thinking in terms of Hawking's 5D light cones here) that they'd rarely if ever even enter into our lives. Now, everything is so much more connected on so many levels, that the veil on this very natural phenomenon has been lifted.
I actually see this as one possible interpretation of the idea of "the dead rising from the grave" at the end times. In previous times, these pseudo-people would be "dead" to us, invisible by virtue of their previous souls having moved onto a different path. Now, they're everywhere, and they feel "dead" to us, and we don't necessarily know why.
In order to not be elitist about the whole thing, I try to remind myself of this concept whenever I get initially creeped out by an OP. That way, instead of continuing to be creeped out or feeling egoic in any way, I try to silently honor the soul of that being who, while not currently in that blank body in front of me, once very much was there, and that thus for at least a little while this body did shelter a real soul and had definite meaning. What remains may be nothing more than the walking dead, an organic machine left behind while still running, running on the inertia of the quickening pace of this time of ours... but that wasn't always the case, and to the extent that there was once deliberate meaning in that vessel, I say Namaste to the Creator that Meaning.